Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ntrk2  neurotrophic tyrosine kinase, receptor, type 2   (Synonyms: C030027L06Rik, Tkrb, trkB)
Results	Reference
1	J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
1	J:212682 Anastasia A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P, Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS One. 2014;9(1):e87406
1	J:178481 Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P, The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Dev Biol. 2011 Dec 1;360(1):77-86
1*	J:201549 Bando T, Morikawa Y, Hisaoka T, Komori T, Miyajima A, Senba E, Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Neurosci Lett. 2013 Aug 26;548:73-8
1	J:65040 Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R, Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000 Feb;114(2):314-20
1	J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
1	J:157721 Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P, Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009 Dec 24;64(6):857-70
1*	J:254788 Chen Z, Donnelly CR, Dominguez B, Harada Y, Lin W, Halim AS, Bengoechea TG, Pierchala BA, Lee KF, p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep. 2017 Oct 17;21(3):707-720
1	J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
1	J:172162 de Melo J, Zhou QP, Zhang Q, Zhang S, Fonseca M, Wigle JT, Eisenstat DD, Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development. Nucleic Acids Res. 2008 Feb;36(3):872-84
1	J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1	J:260552 Donnelly CR, Shah AA, Mistretta CM, Bradley RM, Pierchala BA, Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E516-E525
1	J:64681 Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafii S, Hempstead BL, Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000 Nov;127(21):4531-40
1	J:160718 Dykes IM, Lanier J, Eng SR, Turner EE, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3
1	J:196589 Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R, Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
1	J:253913 Guimaraes-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM, Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5
1	J:345844 Guo Y, Xiang P, Sun X, Liu W, Zhou J, Yin B, Hou L, Qiang B, Li H, Shu P, Peng X, Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
1	J:95688 Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN, Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 2005 Jan 1;19(1):138-51
1	J:54859 Huang EJ, Zang K, Schmidt A, Saulys A, Xiang M, Reichardt LF, POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression. Development. 1999 Jul;126(13):2869-82
1	J:306108 Karpinski BA, Maynard TM, Bryan CA, Yitsege G, Horvath A, Lee NH, Moody SA, LaMantia AS, Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022 Feb 1;15(2):dmm047357
1	J:336177 Keeler AB, Van Deusen AL, Gadani IC, Williams CM, Goggin SM, Hirt AK, Vradenburgh SA, Fread KI, Puleo EA, Jin L, Calhan OY, Deppmann CD, Zunder ER, A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry. Nat Neurosci. 2022 Nov;25(11):1543-1558
1	J:140017 Komori T, Gyobu H, Ueno H, Kitamura T, Senba E, Morikawa Y, Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles. J Comp Neurol. 2008 Nov 1;511(1):92-108
1	J:166964 Lin L, Lee VM, Wang Y, Lin JS, Sock E, Wegner M, Lei L, Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn. 2011 Jan;240(1):52-64
1	J:153555 Mukhopadhyay A, Jarrett J, Chlon T, Kessler JA, HeyL regulates the number of TrkC neurons in dorsal root ganglia. Dev Biol. 2009 Oct 1;334(1):142-51
1	J:134495 Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, Ozaki S, Shiga T, Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development. 2008 May;135(9):1703-11
1	J:239276 Ohayon D, Venteo S, Sonrier C, Lafon PA, Garces A, Valmier J, Rivat C, Topilko P, Carroll P, Pattyn A, Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell. 2015 May 04;33(3):343-50
1	J:207511 Paixao S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R, EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron. 2013 Dec 18;80(6):1407-20
1	J:270955 Peng C, Furlan A, Zhang MD, Su J, Lubke M, Lonnerberg P, Abdo H, Sontheimer J, Sundstrom E, Ernfors P, Termination of cell-type specification gene programs by the miR-183 cluster determines the population sizes of low-threshold mechanosensitive neurons. Development. 2018 Sep 25;145(18):dev165613
1	J:231738 Reed-Geaghan EG, Wright MC, See LA, Adelman PC, Lee KH, Koerber HR, Maricich SM, Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016 Apr 13;36(15):4362-76
1*	J:58028 Russo MA, Giustizieri ML, Favale A, Fantini MC, Campagnolo L, Konda D, Germano F, Farini D, Manna C, Siracusa G, Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis. Biol Reprod. 1999 Oct;61(4):1123-32
1	J:231113 Sajgo S, Ali S, Popescu O, Badea TC, Dynamic expression of transcription factor Brn3b during mouse cranial nerve development. J Comp Neurol. 2016 Apr 1;524(5):1033-61
1*	J:93853 Sedy J, Szeder V, Walro JM, Ren ZG, Nanka O, Tessarollo L, Sieber-Blum M, Grim M, Kucera J, Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn. 2004 Nov;231(3):551-63
1	J:158404 Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T, Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol Cell Neurosci. 2010 Mar;43(3):296-307
1	J:184856 Shintani T, Takeuchi Y, Fujikawa A, Noda M, Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2. J Neurosci. 2012 May 9;32(19):6468-84
1*	J:85731 Spears N, Molinek MD, Robinson LL, Fulton N, Cameron H, Shimoda K, Telfer EE, Anderson RA, Price DJ, The role of neurotrophin receptors in female germ-cell survival in mouse and human. Development. 2003 Nov;130(22):5481-91
1	J:95250 Tamura S, Morikawa Y, Senba E, TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons. Neuroscience. 2005;130(1):223-8
1	J:325765 Tolman Z, Chaverra M, George L, Lefcort F, Elp1 is required for development of visceral sensory peripheral and central circuitry. Dis Model Mech. 2022 May 1;15(5):dmm049274
1	J:340400 Tsai YY, Shen CL, D D, Tsai CY, Tarn WY, Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency. Commun Biol. 2023 Sep 5;6(1):910
1	J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
1	J:83510 Uchida N, Kanazawa M, Suzuki Y, Takeda M, Expression of BDNF and TrkB in mouse taste buds after denervation and in circumvallate papillae during development. Arch Histol Cytol. 2003 Mar;66(1):17-25
1	J:184316 Venteo S, Bourane S, Mechaly I, Sar C, Abdel Samad O, Puech S, Blostein R, Valmier J, Pattyn A, Carroll P, Regulation of the Na,K-ATPase gamma-subunit FXYD2 by Runx1 and Ret signaling in normal and injured non-peptidergic nociceptive sensory neurons. PLoS One. 2012;7(1):e29852
1	J:114095 Vergano-Vera E, Yusta-Boyo MJ, de Castro F, Bernad A, de Pablo F, Vicario-Abejon C, Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells. Development. 2006 Nov;133(21):4367-79
1	J:343072 Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San Jose AS, Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B, Brunet JF, Bellefroid EJ, Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
1	J:167894 Vondran MW, Clinton-Luke P, Honeywell JZ, Dreyfus CF, BDNF+/- mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain. Glia. 2010 May;58(7):848-56
1	J:181639 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C, The transcription factor c-Maf controls touch receptor development and function. Science. 2012 Mar 16;335(6074):1373-6